Department of PA & QA

Research Interests:

  • 1.Main research interests focus on the development/validation of different methods using analytical tools.
  • 2. Chiral Analysis
  • 3. Stability studies of Pharmaceutical compounds.
  • 4. Drug discovery is a costly exercise with a high attrition rate. Our research focuses on improving reactions that are important to medicinal chemistry, e.g. accelerating reactions or simplifying purification processes such that many molecules (a library) can be synthesised over a shorter period of time. Atom economical reactions, where fewer synthetic steps are required, are being employed to modify biologically relevant molecules.

Publications

  • 1. Synthesis and Biological Evaluation of 1,4-Benzodiazepin-2-ones with Antitrypanosomal Activity. Bioorganic & Medicinal Chemistry, 2011, 19, 1802.
  • 2. 1,4-Benzodiazepin-2-ones in Medicinal Chemistry. Mini-Review. Future Medicinal Chemistry, 2010, 2, 1441.
  • 3. Excellent Correlation between Cathepsin B Inhibition and Cytotoxicity for a Series of Palladacycles. Dalton Transactions, 2009, 10731.
  • 4. Synthesis of a 1,4-Benzodiazepine Containing Palladacycle with in Vitro Anticancer and Cathepsin B Activity. Dalton Transactions, 2009, 4299.
  • 5. Microwave Mediated Reduction of Heterocycle and Fluorine Containing Nitroaromatics with Mo(CO)6 & DBU. Tetrahedron, 2008, 64, 10195.
  • 6. C-H Activations on a 1H-1,4-Benzodiazepin-2(3H)-One Template. Tetrahedron, 2008, 64, 6082.
  • 7. Molybdenum Hexacarbonyl & DBU reduction of Nitro Compounds Under Microwave Irradiation. Synlett, 2007, 2557.